Synthesis and Biological Activity of Aliphatic Diesters of Glycyldiethanolamine

This study is devoted to the synthesis of a number of glycine derivatives based on aliphatic diesters of diethanolamine, varying in the length of the hydrocarbon radicals, having potential antibacterial activity. A simple and universal scheme is developed, which makes it possible to form a series of samples in preparative quantities required for biological research. It is stated that the alkyl chain length of the amino acid derivatives of the diethanolamine diesters is important for the demonstrated level of antibacterial activity. The best results with gram-positive and gram-negative bacteria are obtained for compounds with lipophilic chain lengths of the C8 and C10 carbon atoms.