Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives

An unprecedented enantioselective conjugate addition reaction of sodium bisulfite to various nitrostyrenes occurred upon the influence of a bifunctional amino-thiourea organocatalyst; a strategy that opens a straightforward route to unprotected chiral taurine derivatives thanks to the reduction of the obtained β-nitroethanesulfonic acids into the corresponding amino derivatives. An expeditious synthesis of taurine derivatives though a key unprecedented organocatalyzed enantioselective sulfa-Michael addition of bisulfite onto nitrostyrenes.