Longitudinal Change in Quality of Life in Neurological Disorders Measures Over 3Years in Patients with Early Parkinson's Disease

Longitudinal Change in Quality of Life in Neurological Disorders Measures Over 3Years in Patients with Early Parkinson's Disease

BackgroundThe Quality of Life in Neurological Disorders (Neuro‐QoL) is a publicly available health‐related quality‐of‐life measurement system.ObjectiveThe aim of this study was to evaluate the utility of Neuro‐QoL item banks as outcome measures for clinical trials in Parkinson's disease.Methods...

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Veröffentlicht in:Movement disorders 2021-08, Vol.36 (8), p.1979-1983
Hauptverfasser: Marras, Connie, Mills, Kelly A, Eberly, Shirley, Oakes, David, Chou, Kelvin L, Halverson, Matthew, Parashos, Sotirios A, Tarolli, Christopher G, Jin‐Shei Lai, Nowinsky, Cindy J, Suchowersky, Oksana, Farbman, Eric S, Shulman, Lisa M, Simuni, Tanya
Format: Artikel
Sprache:eng
Schlagworte:
Clinical trials
Cognition
Levodopa
Mobility
Movement disorders
Neurodegenerative diseases
Neurological diseases
Neurological disorders
Parkinson's disease
Quality of life
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Zusammenfassung:BackgroundThe Quality of Life in Neurological Disorders (Neuro‐QoL) is a publicly available health‐related quality‐of‐life measurement system.ObjectiveThe aim of this study was to evaluate the utility of Neuro‐QoL item banks as outcome measures for clinical trials in Parkinson's disease.MethodsAn analysis of Neuro‐QoL responsiveness to change and construct validity was performed in a multicenter clinical trial cohort.ResultsAmong 310 participants over 3 years, changes in five of eight Neuro‐QoL domains were significant (P
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.28641