441-P: The Association between Time-in-Range %, Measured by Continuous Glucose Monitoring (CGM) and Physical and Functional Indices amongst Older People with Type 2 Diabetes: A Cross-Sectional Study

People with diabetes have an increased risk for mobility disability and a more rapid decline in muscle mass (sarcopenia) compared to those without diabetes. Studies have demonstrated an association between A1C and Sarcopenia. Less is known regarding the relationship with Time In Range (TIR). Aims: To assess among older people with diabetes type 2, the cross sectional association between: TIR and aerobic capacity, gait speed, strength, balance and frailty indices. Methods: A cross sectional study, conducted amongst people with diabetes over the age of 60. Participants were provided with a blinded CGM system- (I Pro2 carelink, Medtronic) for 1 week and underwent elaborate physical-functional assessment in the beginning and at the end of that week. The association between the % of time in range (TIR) and several physical indices was determined using linear regression. Results: This analysis pertains to 81 men and women. After adjustment for age and gender, a 1% higher TIR (70-180) was associated with a 0.246 higher score on the 6-minute walk score, a measure of aerobic capacity and endurance (P-value=0.019) and 0.212 lower score on the Timed Up and Go(TUG), a measure of fall risk and balance (P-value=0.045). Conclusion: Higher % TIR is associated with better scores on indices of aerobic capacity and a measure predicting falls. Future studies are needed in order to elucidated if glucose levels are merely a marker of disease severity, or if there is possibly a causal relationship.