495-P: The Level of Muscle and Intestinal Damage Biomarkers after an Exercise with a Predominance of Eccentric Contractions in Male Patients with Type 1 Diabetes Mellitus

Eccentric exercises plays a significant role in overall fitness, however, compared to concentric or isometric contractions, it leads to a greater muscle damage due to micro-injuries. Additionally, the redistribution of the blood flow during exercise leads to a reduced blood supply to the intestines and oxidative stress. We aimed to compare the level of muscle and intestinal damage biomarkers after the exercise with a predominance of the eccentric contractions (PEC) between men with type 1 diabetes (T1DM) and healthy controls. We assessed the selected biomarkers after a 30-minute run on the inclined treadmill (10% incline) with a load of 5% of patient BMI with a maximal intensity of 60% of the maximal oxygen uptake. We enrolled 19 male T1DM patients with a mean disease duration of 12.2 ± 6.0 years characterized by very good glycemic control (mean HbA1c 6.9 ± 0.7%, 52 mmol/mol) and 20 healthy men. There were no difference in age (25.3 ± 5.4 vs. 24.3 ± 2.5, p = 0.91), and BMI ( 23.9 ± 2.3 versus 22.8 ± 2.0, p = 0.15) between groups. At baseline patients with T1DM had an increased lactate dehydrogenase (LDH) (Table 1). At 60 minutes and 24 hours after the test, T1DM patients had a higher level of myoglobin, LDH and zonulin compared to healthy men (Table 1). In summary, T1DM male patients seems to be more prone to muscle and intestinal damage after the exercise with PEC.