90-LB: Soliqua (Lixilan): Sustained Long-Term Cost Efficacy and Safety When Used in Combination with Metformin and Glimepiride

Background: Rx with SU and Metformin lowered daily dose of insulin glargine with desirable glycemia. However, Soliqua trials excluded SU and subjects with morbid obesity. Objective: Assess long term efficacy and safety of Soilqua with Glimepiride and Metformin in subjects with type 2 diabetes. Subjects: 31 adults with type 2 diabetes wre identified as currently using Soliqua via EMR. One is excluded as therapy < 3 months. A1c >7.5% with 1) Glimepiride, Metformin and Basal insulin , 2) Metformin and/or DPP 4 inhibitors and/or other SUs and /or GLP1 RA and/or Basal and/or prandial insulin. Subjects with gastroparesis, Triglycerides > 300 mg/dl and pancreatitis are excluded. Methods: Oral drugs besides Glimepiride and Metformin, Basal and prandial insulin and GLP1 RA were stopped. Glimepiride 8 mg, Metformin 1000-2000 mg were started with Soliqua daily dose pre-breakfast based on previous basal insulin dose and increased by 2 units every 3 days until AM sugar >80