366-P: Cystatin C Predicts Incident Diabetes in Angiographied Coronary Patients

Cystatin C is an established marker of renal function, and has also been found to be associated with cardiovascular disease. There is substantial overlap between risk factors for cardiovascular disease and type 2 diabetes; however, it is unclear whether cystatin C predicts new onset diabetes. This issue is addressed in the present study. We prospectively followed 481 consecutive nondiabetic patients undergoing coronary angiography for the evaluation of established or suspected stable coronary artery disease over a follow-up period of 5.5 ± 3.5 years. Overall, 135 patients (28.1%) newly developed diabetes. Cystatin C proved to be a strong predictor of incident diabetes univariately (standardized HR=1.80 [1.14-2.28], p=0.011) and after adjustment for age, gender, hypertension, smoking, LDL cholesterol, HDL cholesterol and fasting glucose (HR=1.86 [1.07-3.21], p=0.027). We conclude that cystatin C is a strong predictor of incident diabetes in angiographied coronary patients.