23-OR: ADA Presidents’ Select Abstract: Genetic Architecture and Novel Genes Implicated in Youth-Onset Type 2 Diabetes

23-OR: ADA Presidents’ Select Abstract: Genetic Architecture and Novel Genes Implicated in Youth-Onset Type 2 Diabetes

Youth-onset type 2 diabetes (T2D) has a strong genetic predisposition and is regarded as a phenotypic extreme of adult-onset T2D. In this study, we aimed to investigate the contribution of rare coding variants to the genetic basis of youth-onset T2D by analyzing whole-exome sequences of 3,005 person...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2021-06, Vol.70 (Supplement_1)
Hauptverfasser: KWAK, SOO HEON, SRINIVASAN, SHYLAJA, CHEN, LING, TODD, JENNIFER, JENSEN, ELIZABETH T., DIVERS, JASMIN, MOTTL, AMY K., PIHOKER, CATHERINE, GANDICA, RACHELLE, LAFFEL, LORI M., ISGANAITIS, ELVIRA M., HAYMOND, MOREY W., LEVITSKY, LYNNE L., POLLIN, TONI I., FLOREZ, JOSE C., FLANNICK, JASON
Format: Artikel
Sprache:eng
Schlagworte:
Beta cells
Diabetes
Diabetes mellitus (non-insulin dependent)
Genes
Genetic diversity
Insulin
Insulin secretion
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Zusammenfassung:Youth-onset type 2 diabetes (T2D) has a strong genetic predisposition and is regarded as a phenotypic extreme of adult-onset T2D. In this study, we aimed to investigate the contribution of rare coding variants to the genetic basis of youth-onset T2D by analyzing whole-exome sequences of 3,005 persons with youth-onset T2D (diagnosed before 20 years of age) from the Progress in Diabetes Genetics in Youth (ProDiGY) consortium and 9,777 ancestry matched adult controls. We identified three genes with aggregate rare variant associations reaching exome-wide significance (P
ISSN:0012-1797
1939-327X
DOI:10.2337/db21-23-OR