962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes
Background: Insulin resistance in pregnancy may be related to ketone synthesis. Data on ketone production in pregnancy and whether they are associated with gestational diabetes (GDM) risk is limited. Methods: A matched case-control study of 107 GDM cases and 214 controls was conducted within the NIC...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2021-06, Vol.70 (Supplement_1) |
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| container_title | Diabetes (New York, N.Y.) |
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| creator | HINKLE, STEFANIE YISAHAK, SAMRAWIT F. ZHAO, SIFANG KATHY TSAI, MICHAEL Y. ZHANG, CUILIN |
| description | Background: Insulin resistance in pregnancy may be related to ketone synthesis. Data on ketone production in pregnancy and whether they are associated with gestational diabetes (GDM) risk is limited. Methods: A matched case-control study of 107 GDM cases and 214 controls was conducted within the NICHD Fetal Growth Studies-Singleton Cohort. Beta hydroxybutyrate (BOH, mmol/L) was measured 4 times in plasma collected at gestational weeks (GW) 10-14, 15-26 (fasted), 23-31, and 33-39. GDM diagnosis and glucose challenge test (GCT) results were extracted from medical records. Prevalence of undetectable ( |
| doi_str_mv | 10.2337/db21-962-P |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2562265995</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2562265995</sourcerecordid><originalsourceid>FETCH-LOGICAL-c635-eef7e21550f33de6195ff69e52ec4b4f06b97341db229acfe52fd81df0da9a0a3</originalsourceid><addsrcrecordid>eNotkE9LAzEUxIMoWKsXP0HAmxDNnyZrvGnVrlBwDz14C283L7Kl3a3JFtxvb2plDu8wPx4zQ8i14HdSqeLe11IwaySrTshEWGWZksXnKZlwLiQThS3OyUVKa865yZqQ8g9-pNUG0hboMw5Ay9HH_mes98MYYUDadrSK-NVB14wUOk8XmAYY2r6DDX1pocYB0yU5C7BJePV_p2T19rqal2z5sXifPy1ZY5RmiKFAKbTmQSmPRlgdgrGoJTazeha4qW2hZiL3kBaakI3gH4QP3IMFDmpKbo5vd7H_3uccbt3vYw6SnNRGSqOt1Zm6PVJN7FOKGNwutluIoxPcHYZyh6Fc7u4q9QuWBlq4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2562265995</pqid></control><display><type>article</type><title>962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>HINKLE, STEFANIE ; YISAHAK, SAMRAWIT F. ; ZHAO, SIFANG KATHY ; TSAI, MICHAEL Y. ; ZHANG, CUILIN</creator><creatorcontrib>HINKLE, STEFANIE ; YISAHAK, SAMRAWIT F. ; ZHAO, SIFANG KATHY ; TSAI, MICHAEL Y. ; ZHANG, CUILIN</creatorcontrib><description>Background: Insulin resistance in pregnancy may be related to ketone synthesis. Data on ketone production in pregnancy and whether they are associated with gestational diabetes (GDM) risk is limited. Methods: A matched case-control study of 107 GDM cases and 214 controls was conducted within the NICHD Fetal Growth Studies-Singleton Cohort. Beta hydroxybutyrate (BOH, mmol/L) was measured 4 times in plasma collected at gestational weeks (GW) 10-14, 15-26 (fasted), 23-31, and 33-39. GDM diagnosis and glucose challenge test (GCT) results were extracted from medical records. Prevalence of undetectable (<0.1), detectable (0.1-<0.2), elevated (0.2-<0.4), and ketoacidosis (≥0.4) BOH were estimated irrespective of GDM. Prospective associations of BOH at GW 10-14 and 15-26 with GDM were estimated using conditional logistic regression; associations with GCT results were estimated using weighted linear regression with robust variance. Results: Percent of women with undetectable, detectable, elevated, and ketoacidosis BOH was 41%, 47%, 10%, and 2% at GW 10-14; 37%, 46%, 15%, and 2% at GW 15-26; 48%, 43%, 9%, and 0% at GW 23-31; and 37%, 57%, 6%, 0% at GW 33-39. Ketoacidosis at 10-14 GW was associated with higher GCT levels (Table). Conclusions: Although few women develop ketoacidosis in pregnancy, detectable ketone levels are common in pregnancy. First trimester ketoacidosis was prospectively associated with higher GCT glucose at GDM screening.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db21-962-P</identifier><language>eng</language><publisher>New York: American Diabetes Association</publisher><subject>Diabetes mellitus ; Fetuses ; Gestational diabetes ; Insulin ; Insulin resistance ; Ketoacidosis ; Ketones ; Medical records ; Pregnancy</subject><ispartof>Diabetes (New York, N.Y.), 2021-06, Vol.70 (Supplement_1)</ispartof><rights>Copyright American Diabetes Association Jun 1, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>HINKLE, STEFANIE</creatorcontrib><creatorcontrib>YISAHAK, SAMRAWIT F.</creatorcontrib><creatorcontrib>ZHAO, SIFANG KATHY</creatorcontrib><creatorcontrib>TSAI, MICHAEL Y.</creatorcontrib><creatorcontrib>ZHANG, CUILIN</creatorcontrib><title>962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes</title><title>Diabetes (New York, N.Y.)</title><description>Background: Insulin resistance in pregnancy may be related to ketone synthesis. Data on ketone production in pregnancy and whether they are associated with gestational diabetes (GDM) risk is limited. Methods: A matched case-control study of 107 GDM cases and 214 controls was conducted within the NICHD Fetal Growth Studies-Singleton Cohort. Beta hydroxybutyrate (BOH, mmol/L) was measured 4 times in plasma collected at gestational weeks (GW) 10-14, 15-26 (fasted), 23-31, and 33-39. GDM diagnosis and glucose challenge test (GCT) results were extracted from medical records. Prevalence of undetectable (<0.1), detectable (0.1-<0.2), elevated (0.2-<0.4), and ketoacidosis (≥0.4) BOH were estimated irrespective of GDM. Prospective associations of BOH at GW 10-14 and 15-26 with GDM were estimated using conditional logistic regression; associations with GCT results were estimated using weighted linear regression with robust variance. Results: Percent of women with undetectable, detectable, elevated, and ketoacidosis BOH was 41%, 47%, 10%, and 2% at GW 10-14; 37%, 46%, 15%, and 2% at GW 15-26; 48%, 43%, 9%, and 0% at GW 23-31; and 37%, 57%, 6%, 0% at GW 33-39. Ketoacidosis at 10-14 GW was associated with higher GCT levels (Table). Conclusions: Although few women develop ketoacidosis in pregnancy, detectable ketone levels are common in pregnancy. First trimester ketoacidosis was prospectively associated with higher GCT glucose at GDM screening.</description><subject>Diabetes mellitus</subject><subject>Fetuses</subject><subject>Gestational diabetes</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Ketoacidosis</subject><subject>Ketones</subject><subject>Medical records</subject><subject>Pregnancy</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNotkE9LAzEUxIMoWKsXP0HAmxDNnyZrvGnVrlBwDz14C283L7Kl3a3JFtxvb2plDu8wPx4zQ8i14HdSqeLe11IwaySrTshEWGWZksXnKZlwLiQThS3OyUVKa865yZqQ8g9-pNUG0hboMw5Ay9HH_mes98MYYUDadrSK-NVB14wUOk8XmAYY2r6DDX1pocYB0yU5C7BJePV_p2T19rqal2z5sXifPy1ZY5RmiKFAKbTmQSmPRlgdgrGoJTazeha4qW2hZiL3kBaakI3gH4QP3IMFDmpKbo5vd7H_3uccbt3vYw6SnNRGSqOt1Zm6PVJN7FOKGNwutluIoxPcHYZyh6Fc7u4q9QuWBlq4</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>HINKLE, STEFANIE</creator><creator>YISAHAK, SAMRAWIT F.</creator><creator>ZHAO, SIFANG KATHY</creator><creator>TSAI, MICHAEL Y.</creator><creator>ZHANG, CUILIN</creator><general>American Diabetes Association</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20210601</creationdate><title>962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes</title><author>HINKLE, STEFANIE ; YISAHAK, SAMRAWIT F. ; ZHAO, SIFANG KATHY ; TSAI, MICHAEL Y. ; ZHANG, CUILIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635-eef7e21550f33de6195ff69e52ec4b4f06b97341db229acfe52fd81df0da9a0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetes mellitus</topic><topic>Fetuses</topic><topic>Gestational diabetes</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Ketoacidosis</topic><topic>Ketones</topic><topic>Medical records</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HINKLE, STEFANIE</creatorcontrib><creatorcontrib>YISAHAK, SAMRAWIT F.</creatorcontrib><creatorcontrib>ZHAO, SIFANG KATHY</creatorcontrib><creatorcontrib>TSAI, MICHAEL Y.</creatorcontrib><creatorcontrib>ZHANG, CUILIN</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HINKLE, STEFANIE</au><au>YISAHAK, SAMRAWIT F.</au><au>ZHAO, SIFANG KATHY</au><au>TSAI, MICHAEL Y.</au><au>ZHANG, CUILIN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><date>2021-06-01</date><risdate>2021</risdate><volume>70</volume><issue>Supplement_1</issue><issn>0012-1797</issn><eissn>1939-327X</eissn><abstract>Background: Insulin resistance in pregnancy may be related to ketone synthesis. Data on ketone production in pregnancy and whether they are associated with gestational diabetes (GDM) risk is limited. Methods: A matched case-control study of 107 GDM cases and 214 controls was conducted within the NICHD Fetal Growth Studies-Singleton Cohort. Beta hydroxybutyrate (BOH, mmol/L) was measured 4 times in plasma collected at gestational weeks (GW) 10-14, 15-26 (fasted), 23-31, and 33-39. GDM diagnosis and glucose challenge test (GCT) results were extracted from medical records. Prevalence of undetectable (<0.1), detectable (0.1-<0.2), elevated (0.2-<0.4), and ketoacidosis (≥0.4) BOH were estimated irrespective of GDM. Prospective associations of BOH at GW 10-14 and 15-26 with GDM were estimated using conditional logistic regression; associations with GCT results were estimated using weighted linear regression with robust variance. Results: Percent of women with undetectable, detectable, elevated, and ketoacidosis BOH was 41%, 47%, 10%, and 2% at GW 10-14; 37%, 46%, 15%, and 2% at GW 15-26; 48%, 43%, 9%, and 0% at GW 23-31; and 37%, 57%, 6%, 0% at GW 33-39. Ketoacidosis at 10-14 GW was associated with higher GCT levels (Table). Conclusions: Although few women develop ketoacidosis in pregnancy, detectable ketone levels are common in pregnancy. First trimester ketoacidosis was prospectively associated with higher GCT glucose at GDM screening.</abstract><cop>New York</cop><pub>American Diabetes Association</pub><doi>10.2337/db21-962-P</doi></addata></record> |
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| identifier | ISSN: 0012-1797 |
| ispartof | Diabetes (New York, N.Y.), 2021-06, Vol.70 (Supplement_1) |
| issn | 0012-1797 1939-327X |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Diabetes mellitus Fetuses Gestational diabetes Insulin Insulin resistance Ketoacidosis Ketones Medical records Pregnancy |
| title | 962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes |
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