962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes

962-P: Plasma Beta Hydroxybutyrate in Pregnancy and Gestational Diabetes

Background: Insulin resistance in pregnancy may be related to ketone synthesis. Data on ketone production in pregnancy and whether they are associated with gestational diabetes (GDM) risk is limited. Methods: A matched case-control study of 107 GDM cases and 214 controls was conducted within the NIC...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2021-06, Vol.70 (Supplement_1)
Hauptverfasser: HINKLE, STEFANIE, YISAHAK, SAMRAWIT F., ZHAO, SIFANG KATHY, TSAI, MICHAEL Y., ZHANG, CUILIN
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes mellitus
Fetuses
Gestational diabetes
Insulin
Insulin resistance
Ketoacidosis
Ketones
Medical records
Pregnancy
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Zusammenfassung:Background: Insulin resistance in pregnancy may be related to ketone synthesis. Data on ketone production in pregnancy and whether they are associated with gestational diabetes (GDM) risk is limited. Methods: A matched case-control study of 107 GDM cases and 214 controls was conducted within the NICHD Fetal Growth Studies-Singleton Cohort. Beta hydroxybutyrate (BOH, mmol/L) was measured 4 times in plasma collected at gestational weeks (GW) 10-14, 15-26 (fasted), 23-31, and 33-39. GDM diagnosis and glucose challenge test (GCT) results were extracted from medical records. Prevalence of undetectable (
ISSN:0012-1797
1939-327X
DOI:10.2337/db21-962-P