Cobalt(II)‐Catalyzed Csp2H Alkynylation/Annulation with Terminal Alkynes: Selective Access to 3‐Methyleneisoindolin‐1‐one

Cobalt(II)‐Catalyzed Csp2H Alkynylation/Annulation with Terminal Alkynes: Selective Access to 3‐Methyleneisoindolin‐1‐one

A highly efficient cobalt(II)‐catalyzed alkynylation/annulation of terminal alkynes assisted by an N,O‐bidentate directing group is described. This protocol is characterized by wide substrate scope utilizing cheap cobalt catalysts, and offers a new approach to 3‐methyleneisoindolin‐1‐one, which can...

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Veröffentlicht in:Angewandte Chemie International Edition 2015-08, Vol.54 (34), p.10012-10015
Hauptverfasser: Lin‐Bao Zhang, Xin‐Qi Hao, Zhan‐Jiang Liu, Xin‐Xiang Zheng, Shou‐Kun Zhang, Jun‐Long Niu, Mao‐Ping Song
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Catalysts
Chemical reactions
Cobalt
Organic chemistry
Substrates
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Zusammenfassung:A highly efficient cobalt(II)‐catalyzed alkynylation/annulation of terminal alkynes assisted by an N,O‐bidentate directing group is described. This protocol is characterized by wide substrate scope utilizing cheap cobalt catalysts, and offers a new approach to 3‐methyleneisoindolin‐1‐one, which can be converted into an oxadiazine salt in one step. Moreover, the directing group could be removed in three steps.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201504962