Upregulation of Bax, TNF-α and down-regulation of Bcl-2 in liver cancer cells treated with HL-7 and HL-10 peptides

Upregulation of Bax, TNF-α and down-regulation of Bcl-2 in liver cancer cells treated with HL-7 and HL-10 peptides

Nowadays, cancer has become a pervasive disease in the world. Due to the side effects of chemotherapeutic agents, the use of peptides has been increasingly popular among scientists. The present study aimed to assess the cell toxicity and the change in the expression of Bcl-2, tumor necrosis factor-a...

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Veröffentlicht in:Biológia 2021-09, Vol.76 (9), p.2735-2743
Hauptverfasser: Setayesh-Mehr, Zahra, Asoodeh, Ahmad, Poorsargol, Mahdiye
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
BAX protein
Bcl-2 protein
Biomedical and Life Sciences
Cancer
Cell Biology
Chemotherapy
Genes
Hepatocytes
Life Sciences
Liver cancer
Lymphocytes
Microbiology
mRNA
Original Article
Peptides
Plant Sciences
Polymerase chain reaction
Side effects
Toxicity
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Zoology
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Zusammenfassung:Nowadays, cancer has become a pervasive disease in the world. Due to the side effects of chemotherapeutic agents, the use of peptides has been increasingly popular among scientists. The present study aimed to assess the cell toxicity and the change in the expression of Bcl-2, tumor necrosis factor-alpha (TNF-α), and Bax genes in HepG2 cancer cell line treated with peptides HL-7 (YLYELAR) and HL-10 (AFPYYGHHLG) using MTT, western blot and real-time polymerase chain reaction (PCR) analyses. The results showed that HL-7 and HL-10 peptides significantly ( p  
ISSN:0006-3088
1336-9563
DOI:10.1007/s11756-021-00800-2