Inside Cover: A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite (ChemMedChem 3/2011)

The inside cover picture shows release of a Plasmodium falciparum DPAP1 inhibitor from a fragmenting hybrid. Iron(II)-promoted scission of a 1,2,4-trioxolane ring in the hybrid produces an initial cytotoxic effect while simultaneously precipitating release of the free DPAP1 inhibitor. Thus, two antiparasitic activities are conferred to the parasite in an iron(II)-dependent fashion. For more information, see the Communication by Matthew Bogyo, AdamR. Renslo, et al. on p.415ff.