Iodine Dosage in Salt Under SNI are Still Providing Normal Value on Iodine Status and Thyroid Function on Women Childbearing Age and School-Aged Children

Background/Aims: There is an increase on the median of urinary iodine (UI) concentration in several regions in Indonesia based on National Iodine Deficiency Disorder Survey 2003, 2013 and the other research require an evaluation of national standards Indonesia for iodized salt (SNI). The Study aimed to estimate an iodine effective dose in salt that ensures normal UI levels and thyroid function for women of childbearing age and school-aged children (SAC). Methods: This is experimental research with a double-blind RCT design in Kepil District, Wonosobo Central of Java. Randomization with randomized block design, large block 8. Intervention group was 15–25 ppm; 25–35 ppm; 35–45 ppm; 45–55 ppm KIO3 in salt for 4 month. The number of samples was 176 women of childbearing age (18–45 years old) and 176 schoolaged children (SAC) 6–12 years old. GLM-RM was used to data analysis by SPSS 22. Results: Median of UI was the optimal range (100–299 μg/L), in both sample group. Median UI and TSH levels were not significantly different in each intervention groups, pre and post study in the both sample group. No overt hypothyroidism and overt hyperthyroidism were found. There was 4% was subclinical hypothyroidism; 1.7% of subclinical hyperthyroidism in SAC group. Subclinical hypothyroidism and subclinical hyperthyroidism was 4.5% respectively in women of childbearing age. Conclusions: The intervention of iodized in salt with 15–55 ppm KIO3 for 4 months still gives normal in median UI value and thyroid function in women of childbearing age and school-aged children.