Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs
The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for...
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| Veröffentlicht in: | The New England journal of medicine 2021-08, Vol.385 (7), p.628-639 |
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| container_end_page | 639 |
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| container_issue | 7 |
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| container_title | The New England journal of medicine |
| container_volume | 385 |
| creator | Schett, Georg McInnes, Iain B Neurath, Markus F |
| description | The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for reclassification. |
| doi_str_mv | 10.1056/NEJMra1909094 |
| format | Article |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-08, Vol.385 (7), p.628-639 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Allergy Arteritis Autoimmune Disease Autoimmune diseases Classification Cytokines Disease Drug therapy Fibroblasts Gastroenterology Genetics Immunity Immunology Immunology General Inflammation Inflammatory Bowel Disease Inflammatory diseases Multiple sclerosis Osteoporosis Pathogenesis Reclassification Rheumatoid Arthritis Rheumatology Rheumatology General Skin Tumor necrosis factor Tumor necrosis factor-TNF Vasculitis |
| title | Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs |
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