Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs

The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for...

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Veröffentlicht in:	The New England journal of medicine 2021-08, Vol.385 (7), p.628-639
Hauptverfasser:	Schett, Georg, McInnes, Iain B, Neurath, Markus F
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy Arteritis Autoimmune Disease Autoimmune diseases Classification Cytokines Disease Drug therapy Fibroblasts Gastroenterology Genetics Immunity Immunology Immunology General Inflammation Inflammatory Bowel Disease Inflammatory diseases Multiple sclerosis Osteoporosis Pathogenesis Reclassification Rheumatoid Arthritis Rheumatology Rheumatology General Skin Tumor necrosis factor Tumor necrosis factor-TNF Vasculitis
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Beschreibung
Zusammenfassung:	The ability to block specific cytokine pathways has revealed pathophysiological differences among autoimmune diseases (e.g., the efficacy of TNF inhibitors in arthritides and inflammatory bowel disorders and their inefficacy in giant-cell arteritis and multiple sclerosis), providing a framework for reclassification.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMra1909094