Synthesis of 2,5-dihydro-3-furans using nano-CoAl2O4

Nano - CoAl 2 O 4 has been used as an efficient catalyst for the preparation of 5-oxo-2,5-dihydro-3 furancarboxylates by multi-component reactions of phenylglyoxal, dimethyl acetylenedicarboxylate and primary amines. The best results were obtained in the presence of 4 mg of nano-CoAl 2 O 4 in CH 2 Cl 2 at room temperature. The structures of the products were deduced from their 1 H NMR, 13 C NMR, FT-IR and elemental analyses. Experimental simplicity, wide range of products, great yields in concise times, the retrievable of the nanocatalyst and low catalyst loading are some of the substantial features of this method . Graphic abstract