DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect m...

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Veröffentlicht in:	Annals of clinical and translational neurology 2021-08, Vol.8 (8), p.1738-1744
Hauptverfasser:	Sormani, Maria Pia, Salvetti, Marco, Labauge, Pierre, Schiavetti, Irene, Zephir, Helene, Carmisciano, Luca, Bensa, Caroline, De Rossi, Nicola, Pelletier, Jean, Cordioli, Cinzia, Vukusic, Sandra, Moiola, Lucia, Kerschen, Philippe, Radaelli, Marta, Théaudin, Marie, Immovilli, Paolo, Casez, Olivier, Capobianco, Marco, Ciron, Jonathan, Trojano, Maria, Stankoff, Bruno, Créange, Alain, Tedeschi, Gioacchino, Clavelou, Pierre, Comi, Giancarlo, Thouvenot, Eric, Battaglia, Mario Alberto, Moreau, Thibault, Patti, Francesco, De Sèze, Jérôme, Louapre, Celine
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Brief Communication Brief Communications Clinical Neurology Coronaviruses COVID-19 Females Hospitalization Life Sciences Life Sciences & Biomedicine Meta-analysis Multiple sclerosis Neurons and Cognition Neurosciences Neurosciences & Neurology Pandemics Science & Technology Severe acute respiratory syndrome coronavirus 2 Standard deviation Systematic review Ventilators
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Zusammenfassung:	We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p
ISSN:	2328-9503 2328-9503
DOI:	10.1002/acn3.51408