Sensitization of nontoxic MOF for their potential drug delivery application against microbial infection

[Display omitted] •Numerous features of nontoxic MOFs as drug carriers for biological adaptabilities were investigated.•Several types of methodologies to functionalize MOFs with appropriate agents for antibacterial and biological application were listed.•A thorough summary of the antibacterial and biomedical applications of MOF nanoparticles has been demonstrated elaborately.•Challenges and future predictions were vigorously studied to provide important context for the improvement of MOFs. Research on metal–organic frameworks (MOFs) for applications in different fields has devoted numerous attempts in current years. Recently the biomedical application of MOFs from drug delivery to medicinal activity has gained a lot of attention to the community. MOFs are appointed as encouraging types of carriers for therapeutic action due to its well structural arrangement, large surface area, tunable pore size, and comfortable for chemical incorporation. In present years, MOF nanoparticles have been used in numerous antimicrobial actions due to their constant drug delivery capability, permeability, and structural flexibility in grouping with several materials (like as nanoparticles, drugs, antibiotics, and polymers). In the present review, several important features of MOFs as drug carriers for biological adaptabilities were investigated. Then, various types of methodologies to functionalize MOFs with satisfying agents were abbreviated. At the end, this review proposes a thorough summary of the biomedical applications of MOF nanoparticles focusing on the antimicrobial activity. Finally, the challenges and predictions were expansively discussed to provide important context for the improvement of MOFs as proficient antibacterial and antiviral actions.