INVESTIGATION OF THE EFFECT OF Allium schoenoprasum L. (SIRMO) PLANT AGAINST ACRYLAMIDE TOXICITY IN RATS

This study was planned to investigate the protective effect of Allium schoenoprasum L. (Sirmo) against acrylamide toxicity. Thirty-two Wistar-Al-bino rats were used as the study animal material. Rats were divided into 4 groups. No application was made to the first group. The second group received 25 mg / kg Acrylamide gastric gavage daily. The third group received 200 mg / kg Allium schoenoprasum L. (Sirmo) ethanol extract by gastric gavage. Fourth group received 25 mg / kg Acrylamide and 200 mg / kg Allium schoenoprasum L. ethanol extract at by gastric gavage. The study period was planned as 15 days. On the 16th day, all rats were sacrificed by high blood collection. As a result of the analysis, TAS levels were decreased and TOS levels were increased in acrylamide group. Allium schoenoprasum L. groups showed increased TAS levels and decreased TOS levels. BUN and HDL levels were decreased in the acrylamide and sirmo group. Zn, Mn and Cu heavy metal levels were decreased in all groups compared to control group. As a result, it was observed that Allium schoenoprasum L. has benefits against oxidative stress caused by acrylamide toxicity. However, ALT and AST levels were increased in groups where this plant was given. In the same groups, BUN levels decreased compared to the control group. These parameters are important indicators showing adverse conditions in the liver. These results are important in the long term, since the plant we use may have harmful effects on the liver.