Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi

Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol (1), which inhibits Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) wi...

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Veröffentlicht in:	Journal of general and applied microbiology 2021, Vol.67(3), pp.114-117
Hauptverfasser:	Pramisandi, Amila, Kurnia, Kesi, Chrisnayanti, Evita, Bernawati, Putri, Dobashi, Kazuyuki, Mori, Mihoko, Mahsunah, Anis Herliyati, Nonaka, Kenichi, Matsumoto, Atsuko, Kristiningrum, Hidayati, Dyah Noor, Dewi, Diana, Prabandari, Erwahyuni Endang, Amalia, Eri, Rahmawati, Yulia, Nurkanto, Arif, Inaoka, Daniel Ken, Waluyo, Danang, Kita, Kiyoshi, Nozaki, Tomoyoshi, Ōmura, Satoshi, Shiomi, Kazuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Dehydrogenase Dehydrogenases Dihydroorotate dehydrogenase Erythrocytes Fungi inhibitor malaria Plasmodium falciparum
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Zusammenfassung:	Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol (1), which inhibits Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 3.4 μM. Another Indonesian fungus, Penicillium citrinum BioMCC-f.T.6730, produced an analog of 1, homogentisic acid (4), which also inhibits PfDHODH with an IC50 value of 47.6 μM.
ISSN:	0022-1260 1349-8037
DOI:	10.2323/jgam.2020.08.004