β-Cyclodextrin-based metal-organic framework as a carrier for zero-order drug delivery

[Display omitted] •β-CD-MOF with double channels structure was prepared for drug delivery.•β-CD-MOF brought a high entrapment efficiency of naringin.•Naringin loaded β-CD-MOF release the drug over 30 days according to zero-order rule.•No cytotoxicity of the drug delivery system was detected in vitro. A zero-order drug delivery system (DDS) is one of the most critical strategies in pharmaceutical technology. Herein, β-cyclodextrins-based metal–organic framework (CD-MOF) with double channel structures was obtained, which was used as a zero-order DDS for loading naringin (NAR). The drug release with a zero-order kinetic rule was observed over 30 days; while a high entrapment efficiency of over 80% was obtained. No negative effect was detected when NAR/CD-MOF co-cultured with MC3T3-E1 cells. Hence, CD-MOF would be a potential carrier for zero-order DDSs.