Reductions in QRS area predict long-term clinical outcomes after cardiac resynchronisation therapy

Background: Some studies have shown that pre-implantation QRS area (QRSarea) predicts clinical outcomes after cardiac resynchronisation therapy (CRT). Objective: To determine whether post-implantation changes in QRSarea predicts clinical outcomes after CRT. Methods: In this retrospective study, QRSa...

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Veröffentlicht in:European journal of arrhythmia & electrophysiology 2019-01, Vol.5, p.20
Hauptverfasser: Oka, O, Zegard, A, PM van Dam, Stegemann, B, Qiu, T, Marshall, H, Leyva, F
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Sprache:eng
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Zusammenfassung:Background: Some studies have shown that pre-implantation QRS area (QRSarea) predicts clinical outcomes after cardiac resynchronisation therapy (CRT). Objective: To determine whether post-implantation changes in QRSarea predicts clinical outcomes after CRT. Methods: In this retrospective study, QRSarea, derived from pre- and post-implantation vectorcardiography (VCG), were assessed in relation to the primary endpoint of cardiac mortality after CRT. Other endpoints included total mortality, total mortality or heart failure (HF) hospitalisation and total mortality or major adverse cardiac events (MACE). Results: In patients (n=380, age 72.0 ± 12.4 years, 68.7% male) undergoing CRT over 7.7 years (median follow-up: 3.8 years [interquartile range 2.3–5.3]), pre-implantation QRSarea ≥ 102 µVs predicted cardiac mortality (HR: 0.36; p < 0.001) as well as total mortality (0.58; p=0.001), total mortality or HF hospitalisation (HR: 0.53) and total mortality or MACE (HR: 0.52) (both p < 0.001). The association of QRSarea with cardiac mortality was independent of known confounders, including QRS duration (QRSd) and morphology (p
ISSN:2058-3869
2058-3877