Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes
Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health, especially among immunocompromised populations. Given the intricate problem of dramatic increase in resistance to common biocides, the development of safe and efficient biocide formulat...
Gespeichert in:
| Veröffentlicht in: | Nano research 2021-08, Vol.14 (8), p.2735-2748 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2748 |
|---|---|
| container_issue | 8 |
| container_start_page | 2735 |
| container_title | Nano research |
| container_volume | 14 |
| creator | Cai, Ling Huang, Yanqiang Duan, Yuanyuan Liu, Qiao Xu, Qilan Jia, Jia Wang, Jianming Tong, Qian Luo, Peipei Wen, Yujie Peng, Luming Wu, Qian Hang, Xudong Jiang, Huijun Zhu, Ping Yang, Yanmei Zhou, Boshen Zeng, Liping Bi, Hongkai Chen, Jin |
| description | Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health, especially among immunocompromised populations. Given the intricate problem of dramatic increase in resistance to common biocides, the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding. In this study, Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine (ε-PL) decorated aldehyde functionalized mesoporous silica SBA-15 (CHO-SBA-15) for the selective coordination of silver ions, which was affirmed by various physicochemical methods. Besides the identified broad-spectrum antibacterial activities, the as-prepared Schiff-base silver nanocomplex (CHO-SBA-15/ε-PL/Ag, CLA-1) exhibited an improved inhibitory effect on infectious pathogen growth typified by
Escherichia coli
and
Staphylococcus aureus
in comparison with two control silver complexes without Schiff-base conjugates, SBA-15/ε-PL/Ag and CHO-SBA-15/Ag, respectively. In addition, CLA-1 remarkably inhibited the growth of
Mycobacterium tuberculosis
due to the excellent antimicrobial activity of silver species. Significantly, CLA-1 kills
Candida albicans
cells, inhibits biofilm formation, and eliminates preformed biofilms, with no development of resistance during continuous serial passaging. The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species. In mouse models of multidrug-resistant
C. albicans
infection, CLA-1 exhibited efficient
in vivo
fungicidal efficacy superior to two antifungal drugs, amphotericin B and fluconazole. Moreover, CLA-1 treatment induces negligible toxicity against normal tissues with safety. Therefore, this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes. |
| doi_str_mv | 10.1007/s12274-020-3279-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2555785855</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2555785855</sourcerecordid><originalsourceid>FETCH-LOGICAL-c316t-ca0893066e377084ec141e370728f919e6dd8d88b76d44b4561088bdb3a145763</originalsourceid><addsrcrecordid>eNp1kc9KxDAQxosouK4-gLeA52qSpkl6lMV_sOBBPYc0nbpZ2mZN0sV9Fx_WlCqeDIHMZL75zcCXZZcEXxOMxU0glAqWY4rzgooq50fZglSVzHE6x78xoew0OwthizGnhMlF9vViNrZt81oHQMF2e_Bo0IMzrt918AkBtc73Olo3oHQHHUevO1Rbt3PdoU9q43SEBvUQ0pd3Y5gw1uhUGKK39ThVo0NxA8j2O-_2KTeJEu0eELQtmDih7TBFdgL01nhXQzjPTlrdBbj4eZfZ2_3d6-oxXz8_PK1u17kpCI-50VhWBeYcCiGwZGAIIynGgsq2IhXwppGNlLXgDWM1KznBKWvqQhNWCl4ss6uZm7b7GCFEtXWjH9JIRcuyFLKUZZlUZFal5ULw0Kqdt732B0WwmkxQswkqmaAmE9REpnNPSNrhHfwf-f-mb88GjaI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2555785855</pqid></control><display><type>article</type><title>Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes</title><source>SpringerLink Journals - AutoHoldings</source><creator>Cai, Ling ; Huang, Yanqiang ; Duan, Yuanyuan ; Liu, Qiao ; Xu, Qilan ; Jia, Jia ; Wang, Jianming ; Tong, Qian ; Luo, Peipei ; Wen, Yujie ; Peng, Luming ; Wu, Qian ; Hang, Xudong ; Jiang, Huijun ; Zhu, Ping ; Yang, Yanmei ; Zhou, Boshen ; Zeng, Liping ; Bi, Hongkai ; Chen, Jin</creator><creatorcontrib>Cai, Ling ; Huang, Yanqiang ; Duan, Yuanyuan ; Liu, Qiao ; Xu, Qilan ; Jia, Jia ; Wang, Jianming ; Tong, Qian ; Luo, Peipei ; Wen, Yujie ; Peng, Luming ; Wu, Qian ; Hang, Xudong ; Jiang, Huijun ; Zhu, Ping ; Yang, Yanmei ; Zhou, Boshen ; Zeng, Liping ; Bi, Hongkai ; Chen, Jin</creatorcontrib><description>Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health, especially among immunocompromised populations. Given the intricate problem of dramatic increase in resistance to common biocides, the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding. In this study, Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine (ε-PL) decorated aldehyde functionalized mesoporous silica SBA-15 (CHO-SBA-15) for the selective coordination of silver ions, which was affirmed by various physicochemical methods. Besides the identified broad-spectrum antibacterial activities, the as-prepared Schiff-base silver nanocomplex (CHO-SBA-15/ε-PL/Ag, CLA-1) exhibited an improved inhibitory effect on infectious pathogen growth typified by
Escherichia coli
and
Staphylococcus aureus
in comparison with two control silver complexes without Schiff-base conjugates, SBA-15/ε-PL/Ag and CHO-SBA-15/Ag, respectively. In addition, CLA-1 remarkably inhibited the growth of
Mycobacterium tuberculosis
due to the excellent antimicrobial activity of silver species. Significantly, CLA-1 kills
Candida albicans
cells, inhibits biofilm formation, and eliminates preformed biofilms, with no development of resistance during continuous serial passaging. The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species. In mouse models of multidrug-resistant
C. albicans
infection, CLA-1 exhibited efficient
in vivo
fungicidal efficacy superior to two antifungal drugs, amphotericin B and fluconazole. Moreover, CLA-1 treatment induces negligible toxicity against normal tissues with safety. Therefore, this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.</description><identifier>ISSN: 1998-0124</identifier><identifier>EISSN: 1998-0000</identifier><identifier>DOI: 10.1007/s12274-020-3279-6</identifier><language>eng</language><publisher>Beijing: Tsinghua University Press</publisher><subject>Aldehydes ; Amphotericin B ; Animal models ; Antibacterial activity ; Antifungal activity ; Antimicrobial activity ; Antimicrobial agents ; Atomic/Molecular Structure and Spectra ; Biocides ; Biocompatibility ; Biofilms ; Biomedicine ; Biopolymers ; Biotechnology ; Cell membranes ; Chemistry and Materials Science ; Condensed Matter Physics ; Drug resistance ; E coli ; Fluconazole ; Fungicides ; Health care facilities ; Imines ; Lysine ; Materials Science ; Microorganisms ; Multidrug resistance ; Nanotechnology ; Poly-L-lysine ; Public health ; Reactive oxygen species ; Research Article ; Silica ; Silicon dioxide ; Silver ; Silver compounds ; Toxicity ; Tuberculosis</subject><ispartof>Nano research, 2021-08, Vol.14 (8), p.2735-2748</ispartof><rights>Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-ca0893066e377084ec141e370728f919e6dd8d88b76d44b4561088bdb3a145763</citedby><cites>FETCH-LOGICAL-c316t-ca0893066e377084ec141e370728f919e6dd8d88b76d44b4561088bdb3a145763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12274-020-3279-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12274-020-3279-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Cai, Ling</creatorcontrib><creatorcontrib>Huang, Yanqiang</creatorcontrib><creatorcontrib>Duan, Yuanyuan</creatorcontrib><creatorcontrib>Liu, Qiao</creatorcontrib><creatorcontrib>Xu, Qilan</creatorcontrib><creatorcontrib>Jia, Jia</creatorcontrib><creatorcontrib>Wang, Jianming</creatorcontrib><creatorcontrib>Tong, Qian</creatorcontrib><creatorcontrib>Luo, Peipei</creatorcontrib><creatorcontrib>Wen, Yujie</creatorcontrib><creatorcontrib>Peng, Luming</creatorcontrib><creatorcontrib>Wu, Qian</creatorcontrib><creatorcontrib>Hang, Xudong</creatorcontrib><creatorcontrib>Jiang, Huijun</creatorcontrib><creatorcontrib>Zhu, Ping</creatorcontrib><creatorcontrib>Yang, Yanmei</creatorcontrib><creatorcontrib>Zhou, Boshen</creatorcontrib><creatorcontrib>Zeng, Liping</creatorcontrib><creatorcontrib>Bi, Hongkai</creatorcontrib><creatorcontrib>Chen, Jin</creatorcontrib><title>Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes</title><title>Nano research</title><addtitle>Nano Res</addtitle><description>Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health, especially among immunocompromised populations. Given the intricate problem of dramatic increase in resistance to common biocides, the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding. In this study, Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine (ε-PL) decorated aldehyde functionalized mesoporous silica SBA-15 (CHO-SBA-15) for the selective coordination of silver ions, which was affirmed by various physicochemical methods. Besides the identified broad-spectrum antibacterial activities, the as-prepared Schiff-base silver nanocomplex (CHO-SBA-15/ε-PL/Ag, CLA-1) exhibited an improved inhibitory effect on infectious pathogen growth typified by
Escherichia coli
and
Staphylococcus aureus
in comparison with two control silver complexes without Schiff-base conjugates, SBA-15/ε-PL/Ag and CHO-SBA-15/Ag, respectively. In addition, CLA-1 remarkably inhibited the growth of
Mycobacterium tuberculosis
due to the excellent antimicrobial activity of silver species. Significantly, CLA-1 kills
Candida albicans
cells, inhibits biofilm formation, and eliminates preformed biofilms, with no development of resistance during continuous serial passaging. The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species. In mouse models of multidrug-resistant
C. albicans
infection, CLA-1 exhibited efficient
in vivo
fungicidal efficacy superior to two antifungal drugs, amphotericin B and fluconazole. Moreover, CLA-1 treatment induces negligible toxicity against normal tissues with safety. Therefore, this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.</description><subject>Aldehydes</subject><subject>Amphotericin B</subject><subject>Animal models</subject><subject>Antibacterial activity</subject><subject>Antifungal activity</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Biocides</subject><subject>Biocompatibility</subject><subject>Biofilms</subject><subject>Biomedicine</subject><subject>Biopolymers</subject><subject>Biotechnology</subject><subject>Cell membranes</subject><subject>Chemistry and Materials Science</subject><subject>Condensed Matter Physics</subject><subject>Drug resistance</subject><subject>E coli</subject><subject>Fluconazole</subject><subject>Fungicides</subject><subject>Health care facilities</subject><subject>Imines</subject><subject>Lysine</subject><subject>Materials Science</subject><subject>Microorganisms</subject><subject>Multidrug resistance</subject><subject>Nanotechnology</subject><subject>Poly-L-lysine</subject><subject>Public health</subject><subject>Reactive oxygen species</subject><subject>Research Article</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Silver</subject><subject>Silver compounds</subject><subject>Toxicity</subject><subject>Tuberculosis</subject><issn>1998-0124</issn><issn>1998-0000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc9KxDAQxosouK4-gLeA52qSpkl6lMV_sOBBPYc0nbpZ2mZN0sV9Fx_WlCqeDIHMZL75zcCXZZcEXxOMxU0glAqWY4rzgooq50fZglSVzHE6x78xoew0OwthizGnhMlF9vViNrZt81oHQMF2e_Bo0IMzrt918AkBtc73Olo3oHQHHUevO1Rbt3PdoU9q43SEBvUQ0pd3Y5gw1uhUGKK39ThVo0NxA8j2O-_2KTeJEu0eELQtmDih7TBFdgL01nhXQzjPTlrdBbj4eZfZ2_3d6-oxXz8_PK1u17kpCI-50VhWBeYcCiGwZGAIIynGgsq2IhXwppGNlLXgDWM1KznBKWvqQhNWCl4ss6uZm7b7GCFEtXWjH9JIRcuyFLKUZZlUZFal5ULw0Kqdt732B0WwmkxQswkqmaAmE9REpnNPSNrhHfwf-f-mb88GjaI</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Cai, Ling</creator><creator>Huang, Yanqiang</creator><creator>Duan, Yuanyuan</creator><creator>Liu, Qiao</creator><creator>Xu, Qilan</creator><creator>Jia, Jia</creator><creator>Wang, Jianming</creator><creator>Tong, Qian</creator><creator>Luo, Peipei</creator><creator>Wen, Yujie</creator><creator>Peng, Luming</creator><creator>Wu, Qian</creator><creator>Hang, Xudong</creator><creator>Jiang, Huijun</creator><creator>Zhu, Ping</creator><creator>Yang, Yanmei</creator><creator>Zhou, Boshen</creator><creator>Zeng, Liping</creator><creator>Bi, Hongkai</creator><creator>Chen, Jin</creator><general>Tsinghua University Press</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>K9.</scope><scope>KB.</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20210801</creationdate><title>Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes</title><author>Cai, Ling ; Huang, Yanqiang ; Duan, Yuanyuan ; Liu, Qiao ; Xu, Qilan ; Jia, Jia ; Wang, Jianming ; Tong, Qian ; Luo, Peipei ; Wen, Yujie ; Peng, Luming ; Wu, Qian ; Hang, Xudong ; Jiang, Huijun ; Zhu, Ping ; Yang, Yanmei ; Zhou, Boshen ; Zeng, Liping ; Bi, Hongkai ; Chen, Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-ca0893066e377084ec141e370728f919e6dd8d88b76d44b4561088bdb3a145763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aldehydes</topic><topic>Amphotericin B</topic><topic>Animal models</topic><topic>Antibacterial activity</topic><topic>Antifungal activity</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Atomic/Molecular Structure and Spectra</topic><topic>Biocides</topic><topic>Biocompatibility</topic><topic>Biofilms</topic><topic>Biomedicine</topic><topic>Biopolymers</topic><topic>Biotechnology</topic><topic>Cell membranes</topic><topic>Chemistry and Materials Science</topic><topic>Condensed Matter Physics</topic><topic>Drug resistance</topic><topic>E coli</topic><topic>Fluconazole</topic><topic>Fungicides</topic><topic>Health care facilities</topic><topic>Imines</topic><topic>Lysine</topic><topic>Materials Science</topic><topic>Microorganisms</topic><topic>Multidrug resistance</topic><topic>Nanotechnology</topic><topic>Poly-L-lysine</topic><topic>Public health</topic><topic>Reactive oxygen species</topic><topic>Research Article</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>Silver</topic><topic>Silver compounds</topic><topic>Toxicity</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Ling</creatorcontrib><creatorcontrib>Huang, Yanqiang</creatorcontrib><creatorcontrib>Duan, Yuanyuan</creatorcontrib><creatorcontrib>Liu, Qiao</creatorcontrib><creatorcontrib>Xu, Qilan</creatorcontrib><creatorcontrib>Jia, Jia</creatorcontrib><creatorcontrib>Wang, Jianming</creatorcontrib><creatorcontrib>Tong, Qian</creatorcontrib><creatorcontrib>Luo, Peipei</creatorcontrib><creatorcontrib>Wen, Yujie</creatorcontrib><creatorcontrib>Peng, Luming</creatorcontrib><creatorcontrib>Wu, Qian</creatorcontrib><creatorcontrib>Hang, Xudong</creatorcontrib><creatorcontrib>Jiang, Huijun</creatorcontrib><creatorcontrib>Zhu, Ping</creatorcontrib><creatorcontrib>Yang, Yanmei</creatorcontrib><creatorcontrib>Zhou, Boshen</creatorcontrib><creatorcontrib>Zeng, Liping</creatorcontrib><creatorcontrib>Bi, Hongkai</creatorcontrib><creatorcontrib>Chen, Jin</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Nano research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Ling</au><au>Huang, Yanqiang</au><au>Duan, Yuanyuan</au><au>Liu, Qiao</au><au>Xu, Qilan</au><au>Jia, Jia</au><au>Wang, Jianming</au><au>Tong, Qian</au><au>Luo, Peipei</au><au>Wen, Yujie</au><au>Peng, Luming</au><au>Wu, Qian</au><au>Hang, Xudong</au><au>Jiang, Huijun</au><au>Zhu, Ping</au><au>Yang, Yanmei</au><au>Zhou, Boshen</au><au>Zeng, Liping</au><au>Bi, Hongkai</au><au>Chen, Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes</atitle><jtitle>Nano research</jtitle><stitle>Nano Res</stitle><date>2021-08-01</date><risdate>2021</risdate><volume>14</volume><issue>8</issue><spage>2735</spage><epage>2748</epage><pages>2735-2748</pages><issn>1998-0124</issn><eissn>1998-0000</eissn><abstract>Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health, especially among immunocompromised populations. Given the intricate problem of dramatic increase in resistance to common biocides, the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding. In this study, Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine (ε-PL) decorated aldehyde functionalized mesoporous silica SBA-15 (CHO-SBA-15) for the selective coordination of silver ions, which was affirmed by various physicochemical methods. Besides the identified broad-spectrum antibacterial activities, the as-prepared Schiff-base silver nanocomplex (CHO-SBA-15/ε-PL/Ag, CLA-1) exhibited an improved inhibitory effect on infectious pathogen growth typified by
Escherichia coli
and
Staphylococcus aureus
in comparison with two control silver complexes without Schiff-base conjugates, SBA-15/ε-PL/Ag and CHO-SBA-15/Ag, respectively. In addition, CLA-1 remarkably inhibited the growth of
Mycobacterium tuberculosis
due to the excellent antimicrobial activity of silver species. Significantly, CLA-1 kills
Candida albicans
cells, inhibits biofilm formation, and eliminates preformed biofilms, with no development of resistance during continuous serial passaging. The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species. In mouse models of multidrug-resistant
C. albicans
infection, CLA-1 exhibited efficient
in vivo
fungicidal efficacy superior to two antifungal drugs, amphotericin B and fluconazole. Moreover, CLA-1 treatment induces negligible toxicity against normal tissues with safety. Therefore, this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.</abstract><cop>Beijing</cop><pub>Tsinghua University Press</pub><doi>10.1007/s12274-020-3279-6</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1998-0124 |
| ispartof | Nano research, 2021-08, Vol.14 (8), p.2735-2748 |
| issn | 1998-0124 1998-0000 |
| language | eng |
| recordid | cdi_proquest_journals_2555785855 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Aldehydes Amphotericin B Animal models Antibacterial activity Antifungal activity Antimicrobial activity Antimicrobial agents Atomic/Molecular Structure and Spectra Biocides Biocompatibility Biofilms Biomedicine Biopolymers Biotechnology Cell membranes Chemistry and Materials Science Condensed Matter Physics Drug resistance E coli Fluconazole Fungicides Health care facilities Imines Lysine Materials Science Microorganisms Multidrug resistance Nanotechnology Poly-L-lysine Public health Reactive oxygen species Research Article Silica Silicon dioxide Silver Silver compounds Toxicity Tuberculosis |
| title | Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T20%3A38%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Schiff-base%20silver%20nanocomplexes%20formation%20on%20natural%20biopolymer%20coated%20mesoporous%20silica%20contributed%20to%20the%20improved%20curative%20effect%20on%20infectious%20microbes&rft.jtitle=Nano%20research&rft.au=Cai,%20Ling&rft.date=2021-08-01&rft.volume=14&rft.issue=8&rft.spage=2735&rft.epage=2748&rft.pages=2735-2748&rft.issn=1998-0124&rft.eissn=1998-0000&rft_id=info:doi/10.1007/s12274-020-3279-6&rft_dat=%3Cproquest_cross%3E2555785855%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2555785855&rft_id=info:pmid/&rfr_iscdi=true |