A New Benzophenone and Bioactive Constituents of Hypericum nokoense
A new benzophenone derivative, hyperinokone ( 1 ), has been isolated from the aerial part of Hypericum nokoense , together with six known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin ( 4 ), 5,4′ -dihydroxy-3′ -...
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| Veröffentlicht in: | Chemistry of natural compounds 2021-07, Vol.57 (4), p.645-649 |
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| container_title | Chemistry of natural compounds |
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| creator | Wu, Fu-Sen Hung, Ching-Ju Lin, Chien-Liang Huang, Hsueh-Yang Kuo, Yueh-Hsiung Chang, Tsung-Hsien Chen, Chun-Lin Sung, Ping-Jyun Cheng, Ming-Jen Kuo, Chu-Wen Chen, Jih-Jung |
| description | A new benzophenone derivative, hyperinokone (
1
), has been isolated from the aerial part of
Hypericum nokoense
, together with six known compounds. The structure of the new compound
1
was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (
4
), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (
5
), and eleocharin A (
6
) exhibited cytotoxicities, with IC
50
values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds
4
and
6
exhibited cytotoxicities, with IC
50
values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition,
3
,
4
, and
6
showed potent inhibition with IC
50
values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation. |
| doi_str_mv | 10.1007/s10600-021-03441-8 |
| format | Article |
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1
), has been isolated from the aerial part of
Hypericum nokoense
, together with six known compounds. The structure of the new compound
1
was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (
4
), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (
5
), and eleocharin A (
6
) exhibited cytotoxicities, with IC
50
values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds
4
and
6
exhibited cytotoxicities, with IC
50
values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition,
3
,
4
, and
6
showed potent inhibition with IC
50
values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation.</description><identifier>ISSN: 0009-3130</identifier><identifier>EISSN: 1573-8388</identifier><identifier>DOI: 10.1007/s10600-021-03441-8</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Organic Chemistry ; Plant Sciences</subject><ispartof>Chemistry of natural compounds, 2021-07, Vol.57 (4), p.645-649</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-401f6fd9e1ef3af4272236104b25ee2e59f98f4ab9e080825c5588f61f0086ac3</citedby><cites>FETCH-LOGICAL-c392t-401f6fd9e1ef3af4272236104b25ee2e59f98f4ab9e080825c5588f61f0086ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10600-021-03441-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10600-021-03441-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Wu, Fu-Sen</creatorcontrib><creatorcontrib>Hung, Ching-Ju</creatorcontrib><creatorcontrib>Lin, Chien-Liang</creatorcontrib><creatorcontrib>Huang, Hsueh-Yang</creatorcontrib><creatorcontrib>Kuo, Yueh-Hsiung</creatorcontrib><creatorcontrib>Chang, Tsung-Hsien</creatorcontrib><creatorcontrib>Chen, Chun-Lin</creatorcontrib><creatorcontrib>Sung, Ping-Jyun</creatorcontrib><creatorcontrib>Cheng, Ming-Jen</creatorcontrib><creatorcontrib>Kuo, Chu-Wen</creatorcontrib><creatorcontrib>Chen, Jih-Jung</creatorcontrib><title>A New Benzophenone and Bioactive Constituents of Hypericum nokoense</title><title>Chemistry of natural compounds</title><addtitle>Chem Nat Compd</addtitle><description>A new benzophenone derivative, hyperinokone (
1
), has been isolated from the aerial part of
Hypericum nokoense
, together with six known compounds. The structure of the new compound
1
was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (
4
), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (
5
), and eleocharin A (
6
) exhibited cytotoxicities, with IC
50
values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds
4
and
6
exhibited cytotoxicities, with IC
50
values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition,
3
,
4
, and
6
showed potent inhibition with IC
50
values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Organic Chemistry</subject><subject>Plant Sciences</subject><issn>0009-3130</issn><issn>1573-8388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kcFOGzEQhq2qlZpSXqCnlXrisDC21177mEQtIEUgFThbZjNON03s1PYWwtNjWCSUS-WD5dH3eWb0E_KNwikFaM8SBQlQA6M18KahtfpAJlS0vFZcqY9kAgC65pTDZ_IlpXV5KinVhMyn1RU-VDP0T2H3G33wWFm_rGZ9sF3u_2E1Dz7lPg_oc6qCqy72O4x9N2wrH_4E9Am_kk_ObhIev91H5O7nj9v5Rb24Pr-cTxd1xzXLdQPUSbfUSNFx6xrWMsYlheaeCUSGQjutXGPvNYICxUQnhFJOUvcyrO34Efk-_ruL4e-AKZt1GKIvLQ0TQnChpaaFOh2pld2g6b0LOdqunCVu-67s5_pSn0qpW9mCbIpwciAUJuNjXtkhJXN58-uQZSPbxZBSRGd2sd_auDcUzEsSZkzClCTMaxJGFYmPUiqwX2F8n_s_1jODAYkw</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Wu, Fu-Sen</creator><creator>Hung, Ching-Ju</creator><creator>Lin, Chien-Liang</creator><creator>Huang, Hsueh-Yang</creator><creator>Kuo, Yueh-Hsiung</creator><creator>Chang, Tsung-Hsien</creator><creator>Chen, Chun-Lin</creator><creator>Sung, Ping-Jyun</creator><creator>Cheng, Ming-Jen</creator><creator>Kuo, Chu-Wen</creator><creator>Chen, Jih-Jung</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20210701</creationdate><title>A New Benzophenone and Bioactive Constituents of Hypericum nokoense</title><author>Wu, Fu-Sen ; Hung, Ching-Ju ; Lin, Chien-Liang ; Huang, Hsueh-Yang ; Kuo, Yueh-Hsiung ; Chang, Tsung-Hsien ; Chen, Chun-Lin ; Sung, Ping-Jyun ; Cheng, Ming-Jen ; Kuo, Chu-Wen ; Chen, Jih-Jung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-401f6fd9e1ef3af4272236104b25ee2e59f98f4ab9e080825c5588f61f0086ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Organic Chemistry</topic><topic>Plant Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Fu-Sen</creatorcontrib><creatorcontrib>Hung, Ching-Ju</creatorcontrib><creatorcontrib>Lin, Chien-Liang</creatorcontrib><creatorcontrib>Huang, Hsueh-Yang</creatorcontrib><creatorcontrib>Kuo, Yueh-Hsiung</creatorcontrib><creatorcontrib>Chang, Tsung-Hsien</creatorcontrib><creatorcontrib>Chen, Chun-Lin</creatorcontrib><creatorcontrib>Sung, Ping-Jyun</creatorcontrib><creatorcontrib>Cheng, Ming-Jen</creatorcontrib><creatorcontrib>Kuo, Chu-Wen</creatorcontrib><creatorcontrib>Chen, Jih-Jung</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Chemistry of natural compounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Fu-Sen</au><au>Hung, Ching-Ju</au><au>Lin, Chien-Liang</au><au>Huang, Hsueh-Yang</au><au>Kuo, Yueh-Hsiung</au><au>Chang, Tsung-Hsien</au><au>Chen, Chun-Lin</au><au>Sung, Ping-Jyun</au><au>Cheng, Ming-Jen</au><au>Kuo, Chu-Wen</au><au>Chen, Jih-Jung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Benzophenone and Bioactive Constituents of Hypericum nokoense</atitle><jtitle>Chemistry of natural compounds</jtitle><stitle>Chem Nat Compd</stitle><date>2021-07-01</date><risdate>2021</risdate><volume>57</volume><issue>4</issue><spage>645</spage><epage>649</epage><pages>645-649</pages><issn>0009-3130</issn><eissn>1573-8388</eissn><abstract>A new benzophenone derivative, hyperinokone (
1
), has been isolated from the aerial part of
Hypericum nokoense
, together with six known compounds. The structure of the new compound
1
was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (
4
), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (
5
), and eleocharin A (
6
) exhibited cytotoxicities, with IC
50
values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds
4
and
6
exhibited cytotoxicities, with IC
50
values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition,
3
,
4
, and
6
showed potent inhibition with IC
50
values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10600-021-03441-8</doi><tpages>5</tpages></addata></record> |
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| subjects | Chemistry Chemistry and Materials Science Chemistry/Food Science Organic Chemistry Plant Sciences |
| title | A New Benzophenone and Bioactive Constituents of Hypericum nokoense |
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