A New Benzophenone and Bioactive Constituents of Hypericum nokoense
A new benzophenone derivative, hyperinokone ( 1 ), has been isolated from the aerial part of Hypericum nokoense , together with six known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin ( 4 ), 5,4′ -dihydroxy-3′ -...
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| Veröffentlicht in: | Chemistry of natural compounds 2021-07, Vol.57 (4), p.645-649 |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A new benzophenone derivative, hyperinokone (
1
), has been isolated from the aerial part of
Hypericum nokoense
, together with six known compounds. The structure of the new compound
1
was determined through spectroscopic and MS analyses. Among the isolates, isojacareubin (
4
), 5,4′ -dihydroxy-3′ -methoxy-(6:7)-2,2-dimethylpyranoflavone (
5
), and eleocharin A (
6
) exhibited cytotoxicities, with IC
50
values of 4.16, 6.28, and 5.98 μM, respectively, against the DLD-1 cell line. Compounds
4
and
6
exhibited cytotoxicities, with IC
50
values of 5.24 and 4.79 μM, respectively, against the IMR-32 cell line. In addition,
3
,
4
, and
6
showed potent inhibition with IC
50
values of 7.67, 6.03, and 10.52 μM, respectively, against LPS-induced NO generation. |
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| ISSN: | 0009-3130 1573-8388 |
| DOI: | 10.1007/s10600-021-03441-8 |