Studies on non-medicinal parts of plant materials: Triterpenes from the roots of Schisandra chinensis

Phytochemical study on a non-medicinal part of a plant material for herbal medicine, the roots of Schisandra chinensis, was conducted to isolate five new triterpenes, schinensins A–D (1–4) and 3-O-methylchangnanic acid (5), together with 21 known compounds including 10 triterpenes, one sterol, two sesquiterpenes, seven lignans, and one flavonoid. The structures of new triterpenes (1–5) were assigned on the basis of spectroscopic analyses aided with TDDFT ECD calculations. Schinensin A (1) was a dinortriterpene possessing 28-norschiartane skeleton, while schinensins B–D (2–4) were assigned as 3,4:9,10-disecocycloartane, 3,4-secocycloartane, and cycloartane triterpenes, respectively. In an evaluation of antiproliferative activities against human cancer cell lines, some triterpenes exhibited significant activities against human breast carcinoma MCF-7 cells as compared to the other cell lines (A549, HeLa, and RPMI8226). [Display omitted] •The roots of Schisandra chinensis are a non-medicinal part.•Phytochemical investigation of the roots gave 26 compounds including 15 triterpenes.•Schinensin A was assigned as a new 28-norschiartane type dinortriterpene.•Some triterpene exhibited significant antiproliferative activity against MCF-7 cells.•A diversity of specialized metabolites of Shisandra chinensis roots was demonstrated.