000168: THE ROLE OF CYCLIN-A, CYCLIN-E AND P-27 IN NORMAL ENDOMETRIUM AND ENDOMETRIAL PATHOLOGIES

Objective: To demonstrate the role of cyclins (Cyclin-A, Cyclin-E) that play role in cell proliferation cycle and the role of P27 gene that is known as tumour supressor gene in endometrial cancer, endometrial hyperplasia and proliferative endometrium by immunohistochemical methods. Material and Methods: This study is carried out among 75 patients; in the first group there were 25 stage I endometrioid type endometrial cancer patients, in the second group there were 25 simple endometrial hyperplasia cases, and in the third group 25 proliferative endometrium cases were included. Results: When groups were compared for Cyclin-E immunoreactivity; there were statistically significant differences between the first group and second group, the first and the third group (P < 0.05). When groups were compared for Cyclin-A immunoreactivity; no statistically significant differences were found among the groups (P > 0.05). When the groups were compared for P27 immunoreactivity; a statistically significant differences were detected among the groups (P < 0.05). Conclusion: As a result, Cyclin-E was found probably to play role in the development of endometrial cancer. P27 was found to be effective at the progression of endometrial hyperplasia and endometrial cancer. It may be proposed that the histopathologic evaluation of Cyclin-E and P27 in patients with endometrial hyperplasia who were planned to be treated medically; these may be important for the evaluation of future development of the endometrial cancer.