000472: UTERINE SARCOMA

Introduction: Uterine sarcomas account for less than 1% of gynae- cologic malignancies and about 2-5% of all uterine cancer. Method: Retrospective study (1980-2000) of prospectively collected data from the Geneva Tumor Registry. Results: 56 patients with sarcomas, all localized in the uterus corpus were found. Median age is 60 years (30-85), 25% (14) are less than 50, 50% (28) are between 50 and 69 and 25% (14) are more than 70 year. The repartition of the different histological types is the following: Leiomyosarcomas 34% (19), Mullerian mixed tumor (heterologous type) 32% (18), Endometrial stromal sarcomas 20% (11), Carcinosarcomas (MMT of homologous type) 9% (5) and sarcomas 5% (3). FIGO staging was used to classified them. 5% (3) diagnosed at the stage 1b and 27% (15) at the stage 4b, in 38 cases the staging is missing. Local metastases were found in 53% of the cases (30), regional metastases in 16% (9) and distant metastases in 27% (15) at the time of the diagnosis (2 cases missing). Surgery was the treatment of choice for 89% (50) patients, associated with radiotherapy in 14% (7) and chemotherapy 20% (10). The median follow up is 6 years. 5 year overall survival was 37% (21), 80% died from uterine sarcoma and 20% died of other causes. Conclusion: Uterine sarcomas are rare cancers, often diagnosed at high stage with poor survival. Due to the difficulty of the diagnosis, a better knowledge of this pathology could improve an early detection and thereby a better treatment.