Preservation of Fertility in Young Women With Endometroid Endometrial Cancer (EEC) Stage I. Long Term Follow Up Using Primary Hormonal Treatment

To analyze the overall survival (OS) and parity of young women with EEC treated with primary hormonal therapy. Between 1990-2001, 7pts (median age 29, range 25-40). with EEC (6 G1 and 1 G2) desiring fertility were included. The staging was made with hysteroscopy, laparoscopy with peritoneal washings, and imaging procedures (pelvic ultrasound scanning, CT scan or MNR). They received 200-500 mg/day of AMP 3 months minimun. All of them are free of disease after a mean of 7 years follow up (2 -12). 6/7pts had complete pathological response. The other one had partial response after 4 month of treatment (she was the G2 tumor), so she received the standard therapy for EEC; pathological examination of the surgical specimen revealed Stage IIIa disease due to a microscopic ovarian metastases. 1/6 with complete response had an endometrial recurrence after 2 years follow up, having no pregnancy. She underwent a TAbHBSO, being at the time of the surgery a stage Ib G1. She is free of disease after 4 years follow up. The others respondent patients are free of disease after 3-12 years follow up. Of them, 3 became pregnant and there were obtained 4 new born, being free of disease after 12,10 and 7 years follow up. Other case, as she is single and has no pregnancy yet, is receiving oral contraceptives. primary hormonal treatment has to be considered as a feasible therapy for young women with endometroid EC stage Ib G1.