Vaginal Metastasis as Presenting Sign of a Renal Adenocarcinoma: A Case Report

Vaginal tumors represent 1-2% of all gynecologic malig-nancies and adenocarcinomas account for 5% of all vaginal neo-plasms. Metastatic vaginal lesions are more frequent than primary ones. Extravaginal origin need to be considered when evaluating vaginal neoplasm. We report a patient who presented with a solitary vaginal metastasis as presenting sign of a renal clear cell adenocar-cinoma. A 56-years-old woman with uterin fibroids presented a polypoid neoformation of the vaginal wall and was submitted to exeresis of the vaginal lesion at the time of abdominal hysterect-omy. Pathologic examination revealed a clear cell adenocarcinoma of the vagina. Restaging was performed with abdominal and pelvic CT scan and demonstrated the presence of a tumor of the left kidney. Radical nephrectomy with para-aortic lynphadenectomy was performed, diagnosis of clear cell carcinoma was placed and immunotherapy with IL-2 was initiated. No other site of disease was detected. A possible origin from metastatic renal clear cell should be considered in case of vaginal tumors.