CP-155 Prevalence and effectiveness of antiretroviral treatment combinations used in hiv patients not included in guidelines

BackgroundMost studies in HIV infected patients focus on the effectiveness of antiretroviral therapy (ART) combinations included in clinical guidelines. However, few studies have analysed combinations not listed in these guidelines.PurposeTo analyse the prevalence and effectiveness of ART combinations not included in HIV guidelines.Material and methodsA retrospective observational study was carried out between January 2014 and December 2015. All patients with ART followed for at least 1 year by the outpatient pharmacy were included. ART were classified in two groups:(1) all combinations listed in the Spanish National AIDS Plan Recommended Guidelines (GESIDA) for initial antiretroviral therapy 2014–2015; and combinations not listed in GESIDA Guidelines.To determine the effectiveness of the treatment, plasma viral load (VL) and CD4+ lymphocytes were reviewed. Two analyses according to different criteria were conducted:(1) criteria reflected in Spanish GESIDA guidelines: VL 300 cells/μL, on at least two consecutive occasions;(2) criteria reflected in the American DHHS guidelines: VL 300 cells/μL, on at least two consecutive occasions. Data were analysed with SPSS 20.0 software.Results245 patients were analysed. 68.6% (168) were men. The median age was 48.5 years (IIC: 43.5 to 53). Patients ART combinations included in guidelinesART combinationsnot included in guidelines Total (n (%)) 224 (91.4) 21 (8.6) VL 300 cells/μL (n (%)) 110 (49.1) 9 (42.9) OR=1.287 95% CI OR: 0.521–3.174 p=0.584 VL 300 cells/μL (n (%)) 174 (77.7) 14 (66.7) OR=1.740 95% CI OR: 0.666–4.545 p=0.253 ConclusionThis study shows that few patients receive ART combinations not included in clinical practice guidelines. The high power of current ART could explain the similar effectiveness between the listed and non-listed therapies in the guidelines.No conflict of interest