DI-022 Use and clinical experience of DOLUTEGRAVIR/ABACAVIR/LAMIVUDINA in a tertiary hospital

BackgroundThe new co-formulated drugs for HIV have made great strides in treating the disease and have achieved excellent health outcomes in patients.PurposeTo analyse the use of dolutegravir/abacavir/lamivudine co-formulated (DTG/ABC/3TC) 50 mg/600 mg/300 mg in HIV infected patients and to evaluate short term effectiveness.Material and methodsA retrospective observational study was conducted in all patients who started DTG/ABC/3TC in our hospital. The variables included were: age, gender, number of previous antiretroviral regimens, patient type (naïve, pretreated), reason for prescription (treatment initiation, switch strategies and virological failure) and viral load (VL) pretreatment and after 4 and 12 weeks.Results33 patients started treatment with DTG/ABC/3TC, and in 3 it was discontinued it. Mean age of the patients was 51 (±13.4) years and 75.7% were men. 81.9% of patients had been previously treated with at least one antiretroviral regimen. Regarding reasons for prescription we found: treatment naïve patients in 18.1%, presence of virologic failure in 15.1% and switch strategies in 66.8%. The switch strategies included 39.5% of prescriptions in order to improve the toxicity and management of comorbidities, 21.3% to avoid drug–drug interactions (mainly with future treatment of hepatitis C), 3% to improve adherence and 3% to avoid enhancing the haematologic toxicity of chemotherapy. Regarding treatment effectiveness: in naïve patients, after 12 weeks of treatment, VL decreased in 3 patients to