DI-076 Clinical experience with darunavir plus cobicistat combination in human immunodeficiency virus treatment

BackgroundDarunavir/cobicistat (DRV/COBI) is an antiviral medicine recently approved in our hospital for simplifying the posology of patients previously treated with darunavir 800 mg and ritonavir 100 mg, in combination with other medicines.PurposeTo evaluate the short term efficacy and safety of DRV/COBI in the treatment of HIV-1 infection.Material and methodsA retrospective observational study was conducted in all patients who initiated therapy with DRV/COBI between November 2015 and July 2016. Data were collected from electronic clinical history and the hospital’s electronic prescribing software. The following variables were collected: sex, age, viral load (VL), creatinine (Cr), transaminases (ALT, AST), and cholesterol (CHO) and triglyceride (TG) blood levels before starting treatment, and 4–8 weeks afterwards. Safety was measured from reported side effects and blood data. Effectiveness was measured by a reduction in VL to