DI-014 Efficacy and safety of fingolimod in patients with relapsing remitting multiple sclerosis

BackgroundFingolimod represents a new class of treatment for patients with relapsing remitting multiple sclerosis (RRMS) because it allows oral administration and it also has a mechanism of action that targets not only the immune system but also neural cells.PurposeTo evaluate the efficacy and adverse effect profile of RRMS patients treated with fingolimod.Material and methodsRetrospective observational study which included all patients aged >18 years with RRMS. Recruitment period: 12 months. Effectiveness was described based on the number of outbreaks during the year prior to treatment and 12 months after receiving the treatment, and also by a subjective score where the patient evaluated his/her current health condition in comparison with the previous year before starting fingolimod (5 item health condition: 1 (much better) to 5 (very much worse)). Safety was assessed in terms of significant adverse effects to fingolimod. Information was obtained across the dispense programme outpatient (Dominion) from where we collected data on: age, sex, diagnosis, treatment, dosage and duration of treatment. Subjects received a questionnaire to be completed at the pharmaceutical consultation at 12 months.Results21 subjects were recruited (n = 21), 71.4% women, mean age 47.3 (23–75) years. 19% of patients had >10 outbreaks during the year prior to the start of fingolimod, 9.5% had between 5 and 10 outbreaks and 42.9% had