Influence of the 2H/1H Isotope Composition of the Water Environment on the Probability of Denaturation Bubble Formation in a DNA Molecule

Influence of the 2H/1H Isotope Composition of the Water Environment on the Probability of Denaturation Bubble Formation in a DNA Molecule

The role of single protium–deuterium exchanges in formation of open-state bubbles is investigated using mathematical modeling methods. It is shown that the probability for formation of bubbles with a certain length (12 to 27 nucleotides) depends on localization of the deuterium atom in the DNA molec...

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Veröffentlicht in:Physics of wave phenomena 2021, Vol.29 (2), p.180-185
Hauptverfasser: Svidlov, A. A., Drobotenko, M. I., Basov, A. A., Elkina, A. A., Gerasimenko, E. O., Malyshko, V. V., Baryshev, M. G., Dzhimak, S. S.
Format: Artikel
Sprache:eng
Schlagworte:
Acoustics
Aqueous Solutions in Biological Systems
Bubbles
Denaturation
Deuterium
Isotope composition
Nucleotides
Physics
Physics and Astronomy
Quantum Optics
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Zusammenfassung:The role of single protium–deuterium exchanges in formation of open-state bubbles is investigated using mathematical modeling methods. It is shown that the probability for formation of bubbles with a certain length (12 to 27 nucleotides) depends on localization of the deuterium atom in the DNA molecule and may be appreciably different from the general probability for occurrence of open states.
ISSN:1541-308X
1934-807X
DOI:10.3103/S1541308X2102014X