Rice Bran Supplement Enhances GSH Levels in Testis and Liver of Carbon Tetrachloride-induced Rats

The dose of 300 mgkg-1 BW RBS had a significantly higher GSH level in testis, while 150 mgkg-1 VA RBS had a significantly higher GSH level in the liver tissue compared to the control group accordingly. [...]the rice bran supplement enhances GSH levels in rat's liver and testis which potentially has protective effects. The GSH/GSSG is considered as an important player in the cellular redox system since it reacts directly with the free radicals and donates an electron to remove the hydrogen peroxide (H2O2) to prevent oxidative stress damage within the cell (Kohen & Nyska, 2002; Szymonik-Lesiuk, 2003; Bender, 2009). [...]any impairment of GSH in living organisms may lead to tissue disorder or injury. Nowadays, the increase of environmental exposure to pollutants, such as pollution, metal exposure, pesticides, and unhealthy lifestyles such as smoking and alcohol consumption, leads to high free radical production in all body tissues, including the testis (Turner & Lysiak, 2008). [...]increased the testis risk for oxidative stress damage. To create the condition which has oxidative stress in several tissues/ organs, in this study we used carbon tetrachloride (CCl4) induction in the animal model. [...]CCl4 induction is proven to have other oxidative damage effects despite the hepatotoxicity known effect (Szymonik-Lesiuk, 2003; Dalton, 2009).