Varfarin ve Bitkisel Ürünlerle Etkileşimi: Vaka raporları, Preklinik ve Klinik Çalışmalar

Warfarin, which is used to treat or prevent atrial fibrillation, venous thromboembolism, deep vein thrombosis, pulmonary embolism, artificial heart valve and myocardial infarction, acts as an anticoagulant by blocking the epoxide reductase enzyme and inhibiting the conversion of vitamin K and vitamin K epoxide. [...]in vivo, in vitro, and clinical studies conducted on plants reported to be interacting in case reports were investigated, and the results obtained regarding the herbal products, dose, duration of use, study type, warfarin dose, and interaction mechanism were presented. The responsibility of healthcare professionals and the importance of selling herbal products under the consultancy of healthcare personnel is emerging in preventing possible adverse drug reactions and toxic effects and ensuring rational drug use. Varfarin ile birlikte kullanıldıǧında A. sativum (sarımsak, garlic), Camellia sinensis (L.) Kuntze (çay, tea), G. biloba (ginkgo, japon eriǧi), P ginseng (ginseng, Korean ginseng), Glycyrrhiza sp. (meyan kökü, licorice), H. perforatum (sarı kantaron, St John's Wort), Punica granatum L. (nar, pomegranate), Salvia miltiorrhiza Bunge (Danşen), Vaccinium macrocarpon (Aiton) Raf (turna yemişi, cranberry), Zingiber officinale Roscoe (zencefil, ginger) ve kumarin içeren bitkilerin (örneǧin Angelica sinensis (Oliv.) Diels, Matricaria recutita L., Peumus boldus (Molina) Looser, M. officinalis (L.) Pall) en fazla etkileşime neden olduǧu belirlenmiştir.