Investigation of GSTM1 and GSTT1 Polymorphisms in Obesity Patients Under Bariatric Surgery

In this study, we investigated the parameters associated with obesity such as body mass index (BMI), TSH, glucose, satiety blood glucose, triglyceride, and cholesterol levels, and deletion polymorphisms of GSTM1 and GSTT1 genes in 152 patients diagnosed with obesity in a Turkish population. Accordin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:FABAD journal of pharmaceutical sciences 2021-06, Vol.46 (2), p.139-146
Hauptverfasser: Ünsal, Abdulkadir, Buluş, Hakan, Dirican, Onur, Oğuztüzün, Serpil, Öztürk, Doǧan, Cihan, Mehmethan, Ada, Ahmet Oǧuz, Işcan, Mümtaz
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In this study, we investigated the parameters associated with obesity such as body mass index (BMI), TSH, glucose, satiety blood glucose, triglyceride, and cholesterol levels, and deletion polymorphisms of GSTM1 and GSTT1 genes in 152 patients diagnosed with obesity in a Turkish population. According to the WHO data, in 2016, there are over 1.9 billion overweight individuals aged 18 and over in the world. Oxidative stress occurs as a result of disruption between the formation of reactive oxygen species (ROS) and the inactivation of these products by the antioxidant defense system and plays an important role in the pathogenesis of many diseases, including inflammation, endothelial dysfunction, and atherosclerotic vascular diseases (Finaud 2006; Bhattacharyya, 2014). Adipose tissue is one of the main sources for ROS formation, and fat accumulation is closely related to increased oxidative stress through nicotinamide adenine dinucleotide phosphate (NADPH), reduced form oxidase activation.
ISSN:1300-4182