A cross-sectional study on association between diabetic retinopathy and glycated hemoglobin level among type 2 diabetes mellitus patients in a tertiary care hospital of Kolkata

Aim and Objective: The aim of the study was to establish the association between glycated hemoglobin A1C (HbA1C) level and presence and severity of DR. Materials and Methods: The present study was conducted in a tertiary care teaching hospital in Kolkata approved by the institutional Research and Ethics Committee. Diabetic Retinopathy; Type 2 Diabetes Mellitus; Glycated Hemoglobin; Non Proliferative Diabetic Retinopathy; Proliferative Diabetic Retinopathy; Neovascularization on Disc; Neovascularization Elsewhere; Advanced Glycation End Product INTRODUCTION Diabetes mellitus (DM) is a large public health problem which affects more than 300 million individuals worldwide with significant morbidity and mortality. Method of Data Collection After collecting 107 Type 2 diabetic patients, Direct ophthalmoscopy (ß Heine-200) was done to detect presence of DR and to perform grading of retinopathy if present and blood was taken for fasting blood sugar (FBS), postprandial blood sugar (PPBS), and HbA1C examination by High Performance Liquid Chromatography method with due permission of institutional Ethics committee. Table 10 shows that high mean value of HbA1C is statistically significant with severity of DR. The Odds ratio in case of HbA1C level (independent variable) and presence or absence of DR (dependent variable) is 1.2909 with 95% Confidence interval between 0.990 and 1.680 and it is not statistically significant (P = 0.06) in our experiment [Table 11].