A photothermal and self-induced Fenton dual-modal antibacterial platform for synergistic enhanced bacterial elimination

[Display omitted] •The intelligent nanocatalyst CP@WS2 NFs was prepared using the in situ growth method.•The nanocatalyst displayed H2O2 self-sufficiency under acidic conditions.•The nanocatalyst had high photothermal conversion efficiency of 40.57 %.•The nanocatalyst exhibited strong antibacterial property in vitro.•The nanocatalyst had high biocompatibility and enhanced wound healing in vivo. Although the single-modal antibacterial technology has received widespread attention, it has limitations because of challenges associated with the complete eradication of bacteria. Herein, we present a synergistic antibacterial strategy based on copper peroxide loaded-tungsten disulfide nanoflowers (CP@WS2 NFs). In this system, copper peroxide can self-supply H2O2 to activate the Fenton reaction, which causes the destruction of some bacteria under acidic condition. Under near-infrared laser irradiation, WS2 NFs transform light-to-localized heat to eliminate the remaining bacteria. The system can cause serious leakage of cell components, reduce the amount of adenosine triphosphate and destroy the bacterial membrane. In vitro experiments indicated a predominant synergistic antibacterial effect on Escherichia coli and Staphylococcus aureus. In vivo experiments of wound healing confirmed that the system can enhance bacterial elimination, concurrently promoting wound healing with high biocompatibility. In addition, our study reveals a promising dimension for the rational design of a synergistic antibacterial system.