MicroRNA‐mediated extracellular matrix remodeling in squamous cell carcinoma of the oral cavity

MicroRNA‐mediated extracellular matrix remodeling in squamous cell carcinoma of the oral cavity

Background We evaluated microRNAs and extracellular matrix component profiles in squamous cell carcinoma of the oral cavity (OSCC) in comparison to healthy mucosa. Methods Retrospective study investigating 64 microRNAs related to oncogenic process and to constituents of the extracellular matrix. We...

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Veröffentlicht in:Head & neck 2021-08, Vol.43 (8), p.2364-2376
Hauptverfasser: Menderico Junior, Gilberto Mendes, Theodoro, Thérèse Rachell, Pasini, Fatima Solange, Menezes Ishikawa, Marina, Santos, Nayara Stephânie Sousa, Mello, Evandro Sobroza, Silva Pinhal, Maria Aparecida, Moyses, Raquel Ajub, Kulcsar, Marco Aurelio Vamondes, Dedivitis, Rogério Aparecido, Cernea, Claudio Roberto, Kowalski, Luiz Paulo, Matos, Leandro Luongo
Format: Artikel
Sprache:eng
Schlagworte:
Carcinogenesis
carcinoma, squamous cell
Collagen (type IV)
Extracellular matrix
Fibroblasts
Laminin
Malignancy
MicroRNAs
miRNA
mouth
Mucosa
Oral cavity
Oral squamous cell carcinoma
Squamous cell carcinoma
Tumor microenvironment
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Zusammenfassung:Background We evaluated microRNAs and extracellular matrix component profiles in squamous cell carcinoma of the oral cavity (OSCC) in comparison to healthy mucosa. Methods Retrospective study investigating 64 microRNAs related to oncogenic process and to constituents of the extracellular matrix. We also performed immunohistochemical assays for molecules involved in the same biological processes. Results High expression of miR‐21‐5p (p 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26686