Assessment of urinary podocalyxin as a marker of glomerular injury in obesity‐related kidney disease in children and adolescents with obesity compared to urinary albumin creatinine ratio

Summary Obesity increases the risk of chronic kidney disease in children. Our aim was to assess urinary podocalyxin (PCX) in children and adolescents with obesity as a potential marker of obesity‐related kidney disease (ORKD). The current case‐control study included 128 children with obesity compared to 60 non‐obese age and sex matched controls. Study population were subjected to full history taking as well as thorough physical examination. Urine samples for albumin creatinine ratio (uACR) and PCX were collected from the study population as well as blood samples for assessment of serum creatinine and fasting lipid profile. A statistically significant difference was found between cases and controls regarding urinary PCX (P