Antimicrobial effects of vanillin‐based pyridyl‐benzylidene‐5‐fluoroindolins

In this study, the antimicrobial effect and DNA gyrase inhibitor potential of vanillin‐based pyridyl–substituted fluoro‐indolines were evaluated. These compounds are synthesized and established through green‐chemistry approaches. The inhibition effect on both DNA gyrase A and B was evaluated in silico and in vitro. Agar well diffusion method–based antimicrobial activity against Gram‐ve Pseudomonas aeruginosa (MTCC 424) and Escherichia coli (MTCC 443), Gram+ve Streptococcus pyogenes (MTCC 442) and Staphylococcus aureus (MTCC 96), and a clinical isolate of Candida albicans (Fungi) was evaluated. The cytotoxicity of the compounds was assessed over macrophages using the MTT assay. In the results, the target compounds exhibited a broad‐spectrum antimicrobial activity against both bacterial types and fungal. ​