A Survey on Prediction of Protein-Protein Interactions

Proteins interacts with one other to form complexes for performing the biological process in a cell. Understanding the interactions of proteins helps in recognizing the disease mechanisms. It plays a major part in the catalytic reaction, drug ability of the molecules. The wet-lab methods are tedious and expensive. However, the data that is identified in experimental methods can be processed and used. Advancement in the field led the prediction using computational approaches for signaling pathways and the recognizable proof for specific diseases. Identification of protein-protein interaction offers a way for advancements of therapeutic methods and drug design. In this paper, an analysis of prediction methodologies that are used for protein-protein interactions was described. Experimental methods and six different computational methods were discussed.