UNACYLATED GHRELIN PLASMA LEVELS ARE LOWER AND PREDICT 5-YEAR LOW MUSCLE MASS IN ELDERLY OBESE SUBJECTS

UNACYLATED GHRELIN PLASMA LEVELS ARE LOWER AND PREDICT 5-YEAR LOW MUSCLE MASS IN ELDERLY OBESE SUBJECTS

Aging-associated skeletal muscle loss may be paralleled by increased fat mass, both contributing to frailty and related healthcare and social costs. In general population cohorts, unacylated ghrelin (UnAG) plasma levels, an emerging modulator of skeletal muscle metabolism with potential muscle-anabo...

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Veröffentlicht in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2021-08, Vol.87-88, p.111316, Article 111316
Hauptverfasser: Cappellari, G. Gortan, Semolic, A., Cremasco, G., Vinci, P., Zanetti, M., Barazzoni, R.
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Bioelectricity
Body fat
Body mass index
Body size
Body weight
Gender
Geriatrics
Ghrelin
Indexing
Inflammation
Metabolism
Multiple regression analysis
Muscles
Musculoskeletal system
Obesity
Older people
Overweight
Plasma levels
Population
Population studies
Regression analysis
Skeletal muscle
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Zusammenfassung:Aging-associated skeletal muscle loss may be paralleled by increased fat mass, both contributing to frailty and related healthcare and social costs. In general population cohorts, unacylated ghrelin (UnAG) plasma levels, an emerging modulator of skeletal muscle metabolism with potential muscle-anabolic actions, decrease in overweight-obese subjects [body mass index (BMI)> 25 kg/m2]. Potential associations between UnAG, overweight-obesity and muscle mass (MM) in elderly humans are currently unknown. In 450 elderly individuals (age>65y; M/F: 179/271) from the North-East Italy MoMa population study we investigated potential associations between ghrelin profile [total (TG), acylated (AG) and unacylated hormone (UnAG)] and body mass index (BMI). MM index (MM/m2) was measured in 133 subjects (M/F: 72/81) by bioelectrical impedance analysis after 5 years. Low MM-index cut-off was defined as two standard deviation lower than average MM-index in young (18-39) reference subjects from the same population. In elderly subjects, UnAG was lower (p
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2021.111316