Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

We report our investigation into the MCU-inhibitory activity of Co 3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-06, Vol.57 (5), p.6161-6164
Hauptverfasser: Woods, Joshua J, Rodriguez, Madison X, Tsai, Chen-Wei, Tsai, Ming-Feng, Wilson, Justin J
Format: Artikel
Sprache:eng
Schlagworte:
Molecular docking
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We report our investigation into the MCU-inhibitory activity of Co 3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore. The MCU-inhibitory properties and mechanisms of action of Co 3+ amine complexes and Ru265 are described.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc01623g