Innovative strategies of hydrogen peroxide-involving tumor therapeutics

Hydrogen peroxide (H 2 O 2 ) with a high level in solid tumor microenvironments has been widely investigated as an important target in the design and application of various novel anticancer strategies. Among these strategies, H 2 O 2 can be used as an oxygen supplier to improve the therapeutic effects of hypoxia-limited treatment modes including chemotherapy (CT), radiotherapy (RT), photodynamic therapy (PDT), sonodynamic therapy (SDT), and starvation therapy (ST). Moreover, it can participate in Fenton or Fenton-like reactions to produce &z.rad;OH with increased toxicity for chemodynamic therapy (CDT). H 2 O 2 -involving CDT can also be combined with other anticancer therapies, such as CT, RT, PDT, SDT, photothermal therapy, and ST, to achieve better anticancer effects than the single treatment mode. In this review, various recently reported anticancer treatments involving H 2 O 2 were summarized. Future prospects inspired by these excellent studies were also discussed to promote the development of the anticancer field involving H 2 O 2 . In this review, we summarized and discussed the recent advances and future prospects of H 2 O 2 -involving therapeutic methods for anticancer applications.