Vitamin D Levels in COVID-19 Outpatients from Western Mexico: Clinical Correlation and Effect of Its Supplementation

Background: The immunomodulatory effects of vitamin D are known to be beneficial in viral infections; it is also known that its deficiency is associated with a prognosis more critical of Coronavirus Disease 2019. This study aimed to determine baseline vitamin D serum concentrations and the effects o...

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Veröffentlicht in:Journal of clinical medicine 2021-05, Vol.10 (11), p.2378, Article 2378
Hauptverfasser: Sanchez-Zuno, Gabriela Athziri, Gonzalez-Estevez, Guillermo, Matuz-Flores, Monica Guadalupe, Macedo-Ojeda, Gabriela, Hernandez-Bello, Jorge, Mora-Mora, Jesus Carlos, Perez-Guerrero, Edsaul Emilio, Garcia-Chagollan, Mariel, Vega-Magana, Natali, Turrubiates-Hernandez, Francisco Javier, Machado-Sulbaran, Andrea Carolina, Munoz-Valle, Jose Francisco
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Sprache:eng
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Zusammenfassung:Background: The immunomodulatory effects of vitamin D are known to be beneficial in viral infections; it is also known that its deficiency is associated with a prognosis more critical of Coronavirus Disease 2019. This study aimed to determine baseline vitamin D serum concentrations and the effects of its supplementation in asymptomatic or mildly symptomatic Coronavirus Disease 2019 outpatients. Methods: 42 outpatients were included, 22 of which received a supplement of 10,000 IU of vitamin D3 for 14 days; the remaining 20 outpatients were designated as a control group. Serum levels of transferrin, ferritin, vitamin D, and D-dimer were measured at baseline in both groups. After 14 days, serum levels of total vitamin D were determined in the supplemented group. Results: At baseline, only 19% of infected outpatients had vitamin D levels corresponding to sufficiency. All outpatients with vitamin D insufficiency had at least one symptom associated with the disease, while only 75% of patients with symptoms presented sufficiency. On the seventh and fourteenth day of follow-up, the supplemented group presented fewer symptoms with respect to those non-supplemented. A vitamin D3 dose of 10,000 IU/daily for 14 days was sufficient to raise vitamin D serum concentrations. Conclusions: Immunomodulatory effects of vitamin D appear to be linked to the development of symptoms in positive outpatients. Vitamin D supplementation could have significant benefits in the Western Mexican population.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10112378