The survival benefit of surgery for perihilar cholangiocarcinoma in octogenarians: Shinshu University experience

Background and Objectives In today's aging society, surgery is increasingly performed for older patients with perihilar cholangiocarcinoma (PHCC). This study aimed to examine survival and oncological outcomes in octogenarians with PHCC who underwent surgery. Methods We retrospectively examined 480 consecutive PHCC patients treated for PHCC between 1991 and 2020. Two hundred forty‐seven underwent resection. Patient and clinical characteristics, including postoperative complications, overall survival (OS), and disease‐free survival (DFS) were analyzed. Results The proportion of octogenarians with PHCC undergoing surgery increased from 5.2% in 1991–2000 to 13.4% in 2016–2020. R0 resection and postoperative complication rates were comparable between octogenarians and younger patients. Five‐year OS (30.0% vs. 31.7%) and DFS (20.0% vs. 29.5%) did not significantly differ. One‐year OS was significantly better in octogenarians who underwent resection than those who did not (95.0% vs. 17.6%; p